Dipeptide caspase inhibitors and the use thereof

Details Dipeptide caspase inhibitors and the use thereof Dipeptide caspase inhibitors and the use thereof

A - Human Necessities

61

K

A61K 38/05 (2006.01) C07K 5/023 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2323439

The present invention is directed to novel dipeptides thereof, represented by general Formula (I): where R1-R2 and AA are defined herein. The present invention relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

La présente invention concerne de nouveaux dipeptides représentés par la formule générale (I) dans laquelle R¿1?-R¿2? et AA ont la notation ci-définie. La présente invention concerne la découverte que des composés ayant la formule (I) sont de puissants inhibiteurs des caspases et de la mort cellulaire apoptotique. Par conséquent, les inhibiteurs de cette invention peuvent retarder ou bloquer la mort cellulaire dans divers états cliniques dans lesquels se produit la perte de cellules, de tissus ou d'organes entiers.

Affiliated with

Also associated with

Rating

Dipeptide caspase inhibitors and the use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dipeptide caspase inhibitors and the use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dipeptide caspase inhibitors and the use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1763959