Pharmaceutical compositions and process for making them

Details Pharmaceutical compositions and process for making them Pharmaceutical compositions and process for making them

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/00 (2006.01) A61K 31/192 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2694378

Amorphous HMG CoA reductase inhibitors, especially amorphous atorvastatin, are described. Also described are pharmaceutical combinations comprising amorphous HMG CoA reductase inhibitors in combination with cholesterol absorption inhibitors or fibrates. A method of manufacturing the compositions using a hot melt extrusion process are also described.

L'invention concerne des inhibiteurs de HMG-CoA réductase sous forme amorphe, et notamment de l'atorvastatine amorphe. L'invention concerne également des combinaisons pharmaceutiques comprenant des inhibiteurs de HMG-CoA réductase sous forme amorphe en combinaison avec des inhibiteurs de l'absorption du cholestérol ou des fibrates. L'invention se rapporte en outre à un procédé de préparation de ces compositions au moyen d'une technique d'extrusion à chaud.

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