Topical hydrogel composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/65 (2006.01) A61K 9/14 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2734687

Compositions for topical application to the skin and/or a wound are disclosed. In some embodiments, the compositions include a suspension or dispersion of particles of at least one poorly soluble drug chelated or otherwise complexed with a metal salt. The compositions may further contain at least one stabilizer, at least one excipient, and at least one physiologically acceptable carrier. Methods for making such compositions, pharmaceutical formulations containing such compositions, and methods of treatment utilizing such compositions are also disclosed.

L'invention porte sur des compositions destinées à une application topique à la peau et/ou une lésion. Dans certains modes de réalisation, les compositions comprennent une suspension ou une dispersion de particules d'au moins un médicament très peu soluble chélaté ou autrement complexé à un sel métallique. Les compositions peuvent en outre contenir au moins un stabilisant, au moins un excipient et au moins un support physiologiquement acceptable. L'invention porte également sur des procédés de fabrication de telles compositions, sur des formulations pharmaceutiques contenant de telles compositions et sur des procédés de traitement utilisant de telles compositions.

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