Synthetic peptides with immunomodulating activity and their...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/00 (2006.01) A61K 38/16 (2006.01) A61K 39/39 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2076877

ABSTRACT There are described new immunomodulator peptides of the general formula R1-aa1-aa2-aa3-aa4-aa5-Pro-aa7-aa8-aa9-aa10- aa11-aa12-aa13-aa14-aa15-R2 in which R1 represents H, R2 represents OH, or else R1 and R2 represent each an amino acid residue or peptide chains, equal or different, containing from 2 to 10 amino acid resi- dues, in such a way that when R1=H and R2=OH, the formula represents a pentadecapeptide in which the N-terminal and C-terminal amino acids are respectively aa1 and aa15; aa2 is a Val, Leu, Ile, Ala, Lys or Gly residue, aa11 is a Glu or Asp residue; and the rest of the amino acid residues aa? different from aa2 and aa11 may be any of the 20 natural amino acids. The incubation of these peptides with lymphomono- nuclear cells obtained from peripheral blood increases their cytotoxic activity towards K562 and Daudi cells used as tumour target cells. Proliferation of the lymphomononuclear cells is induced together with an increase in the number and proportion of CD14+, CD56+ and CD11b+ cells. These peptides are useful in biotherapy of cancer, and also as reagents to evaluate the cellular responsiveness of the immune system.

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