Curcumin analogues and uses thereof

Details Curcumin analogues and uses thereof Curcumin analogues and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 69/76 (2006.01) C07C 49/105 (2006.01) C07C 49/248 (2006.01) C07C 49/255 (2006.01) C07C 49/755 (2006.01) C07C 49/84 (2006.01) C07C 59/84 (2006.01) C07C 69/738 (2006.01) C07C 205/45 (2006.01)

Patent

CA 2482002

The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

La présente invention concerne des composés qui sont capables d'agir en tant qu'antagonistes du récepteur d'androgène, des formulations pharmaceutiques contenant ces derniers et des méthodes d'utilisation desdits composés. Les utilisations comprennent, sans aucune limitation, l'utilisation en tant qu'agents antitumoraux, notamment pour le traitement des cancers tels que le cancer du côlon, de la peau et de la prostate et l'utilisation pour induire l'activité d'antagoniste du récepteur d'androgène chez un individu atteint d'un trouble lié à l'androgène. Des exemples de troubles liés à l'androgène comprennent, sans aucune limitation, la calvitie, l'hirsutisme, les troubles du comportement, l'acné et la spermatogenèse non inhibée alors que l'inhibition de la spermatogenèse est souhaitée.

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