Sulphonylpiperidine derivatives containing an aryl or...

Details Sulphonylpiperidine derivatives containing an aryl or... Sulphonylpiperidine derivatives containing an aryl or...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61P 37/00 (2006.01) C07D 211/96 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2492086

A compound of formula (1), wherein B is an ortho substituted monocyclic aryl or heteroaryl group or a bicyclic aryl or heteroaryl group; useful in the inhibition of one or more metalloproteinases, and in particular TACE.

Cette invention a trait à un composé correspondant à la formule (I). Dans cette formule, B représente un groupe aryle ou hétéroaryle monocyclique ou un groupe aryle ou hétéroaryle bicyclique ortho substitué. Ce composé se révèle des plus utile s'agissant d'inhiber une ou plusieurs métalloprotéases, notamment l'enzyme de conversion de facteur de nécrose tumorale .alpha. (TACE).

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