Pharmaceutical composition of lyophilized formulation and...

Details Pharmaceutical composition of lyophilized formulation and... Pharmaceutical composition of lyophilized formulation and...

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2748365

Disclosed is a pharmaceutical composition of a lyophilized formulation including a multiblock copolymer in which two or more ABA-type triblocks are covalently connected through biodegradable dicarboxylic linkage, wherein A represents a polyethylene oxide block and B represents a polypropylene oxide block, a polybutylene oxide block, or a block of copolymer of propylene oxide and butylene oxide, the multiblock copolymer being included in an amount of 1 to 7 wt% based on the total weight of solution prior to the lyophilized formulation. The composition is capable of reducing reconstitution time of a lyophilized sustained-release formulation.

La présente invention concerne une composition pharmaceutique d'une formule lyophilisée comprenant un copolymère multi-bloc où deux tri-blocs de type ABA ou plus sont liés de façon covalente par des ponts dicarboxyliques biodégradables, A représentant un bloc polyoxyde d'éthylène et B représentant un bloc polyoxyde de propylène, un bloc polyoxyde de butylène ou un bloc de copolymère d'oxyde de propylène et d'oxyde de butylène, le copolymère multi-bloc étant inclus à une teneur comprise entre 1 et 7 % en masse par rapport à la masse totale de la solution avant la formule lyophilisée. La composition peut réduire la durée de reconstitution d'une formule lyophilisée à libération prolongée.

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