Traf inhibitors

Details Traf inhibitors Traf inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2227174

The invention concerns novel inhibitors of tumor necrosis factor receptor associated factor-(TRAF) mediated signal transduction. The invention encompasses the novel inhibitor proteins (I-TRAFs), nucleic acid encoding them, methods for their recombinant production, and their use in screening assays and as pharmaceuticals.

L'invention concerne de nouveaux inhibiteurs de la transduction d'un signal provoquée par le facteur associé au récepteur du facteur de nécrose tumorale (TRAF). Elle concerne les nouvelles protéines d'inhibiteur (I-TRAFs), les acides nucléiques les codant, des procédés servant à les produire de façon recombinante, ainsi que leur utilisation dans des méthodes de criblage et en tant qu'agents pharmaceutiques.

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