Use of ibandronate for promoting osseointegration of...

Details Use of ibandronate for promoting osseointegration of... Use of ibandronate for promoting osseointegration of...

A - Human Necessities

61

K

A61K 31/663 (2006.01) A61K 31/66 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2353528

The invention relates to use of ibandronic acid (1-hydroxy-3-(N-methyl-N- pentyl)aminopropyl-1,1-diphosphonic acid) or physiologically compatible salts or esters thereof for improving the osseointegration of cement-free anchored endoprostheses. Ibandronate or salts thereof is applied for a short time immediately after insertion of an endoprosthesis, with the surprising result that secondary stability of the implant is obtained in only 5 weeks or less after the operation.

L'invention concerne l'utilisation d'acide ibandronique (1-hydroxy-3-(N-méthyl-N-pentyl)aminopropyl-1,1-acide diphosphonique) ou de sels ou d'esters physiologiquement compatibles pour améliorer l'osséointégration d'endoprothèses ancrées sans ciment. Le procédé selon l'invention consiste à appliquer de l'ibandronate ou des sels de ce dernier pendant un laps de temps court après l'insertion d'une endoprothèse, ce qui permet, de manière surprenante, d'obtenir une stabilité secondaire de l'implant seulement cinq semaines ou moins après l'opération.

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