C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 39/09 (2006.01) C12N 9/52 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2354508
Novel vaccines for use against .beta.-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal against .beta.-hemolytic Streptococcus colonization or infection by administering such a vaccine. Enzymatically inactive SCP, and polynucleotides encoding these SCP proteins are further disclosed.
La présente invention concerne des vaccins convenant contre la colonisation ou l'infection par le streptocoque .beta.-hémolytique. Ces vaccins contiennent une quantité immunogène d'une variante de la peptidase C5a streptococcique (SCP). L'invention concerne également un procédé conférant à un mammifère sensible une protection contre la colonisation ou l'infection par le streptocoque .beta.-hémolytique, lequel procédé consiste en une administration d'un tel vaccin. L'invention concerne en outre une peptidase C5a streptococcique enzymatiquement inactive ainsi que des polynucléotides codant les protéines de cette peptidase C5a streptococcique.
Cleary Paul Patrick
Stafslien Deborah K.
Gowling Lafleur Henderson Llp
Regents Of The University Of Minnesota
LandOfFree
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