Casein derived peptides and therapeutic uses thereof

Details Casein derived peptides and therapeutic uses thereof Casein derived peptides and therapeutic uses thereof

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 31/00 (2006.01) A61P 37/04 (2006.01) C07K 1/14 (2006.01) C07K 5/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2558155

Biologically active peptides that are derived from or are similar to sequences of the alphaS1-, alphaS2-, beta- or kapa-casein fractions of milk casein. These peptides are capable of immune modulation and other therapeutic activities, including but not limited to stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non- toxic and can be used to treat and prevent immune pathologies, diabetes, hypercholesterolemia, hematological disorders and viral-related diseases.

L'invention concerne des peptides biologiquement actifs dérivés de séquences des fractions alphaS1-, alphaS2-, bêta- ou kapa-caséine provenant de la caséine du lait ou identiques à ces séquences. Lesdits peptides sont capables de modulation immunitaire et d'autres activités thérapeutiques, notamment de stimuler et améliorer une réponse immunitaire, de protéger contre une infection virale, de normaliser les niveaux de cholestérol sérique et de stimuler l'hématopoïèse. Ces peptides dérivés de la caséine sont non toxiques et peuvent être utilisés pour traiter et prévenir des pathologies immunitaires, le diabète, l'hypercholestérolémie, les troubles hématologiques et les maladies virales correspondantes.

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