C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 209/08 (2006.01) C07D 215/08 (2006.01) C07D 223/16 (2006.01) C07D 225/06 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2091216
Condensed Heterocyclic Ketone Derivatives, Their Production and Use Abstract of the Disclosure A compound of the formula: Image [I] wherein R1 is H or an optionally substituted hydrocarbon or acyl group; ring A is an optionally further substituted benzene ring; n is an integer of 1 to 10; R2, R3 and R4 are H or an optionally substituted hydrocarbon group; R3 and R4 may form an optionally substituted heterocyclic group, taken together with the adjacent nitrogen atom; k is an integer of 0 to 3; and m is an integer of 1 to 8; provided that when k=0 and m=2, n is an integer of not less than 2 or a pharmaceutically acceptable salt thereof, exhibiting excellent cholinesterase inhibitory activity and monoamine reuptake inhibitory activity, thus being useful as therapeutic/prophylactic medicaments of senile dementia.
Goto Giichi
Ishihara Yuji
Miyamoto Masaomi
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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