T-cell epitopes in staphylococcal enterotoxin b

Details T-cell epitopes in staphylococcal enterotoxin b T-cell epitopes in staphylococcal enterotoxin b

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/085 (2006.01) A61K 48/00 (2006.01) C07K 14/31 (2006.01)

Patent

CA 2496242

The present invention relates to the field of immunology. The invention identifies determinants on staphylococcal enterotoxin B (SEB) able to evoke an immune response. In particular the invention is concerned with the identification of epitopes for T-cells in SEB. The invention relates furthermore to T-cell epitope peptides derived from SEB by means of which it is possible to create modified SEB variants with reduced immunogenicity.

L'invention concerne le domaine de l'immunologie. L'invention identifie des déterminants sur l'entérotoxine staphylococcique B (SEB) qui sont capables d'induire une réponse immunitaire. L'invention concerne plus particulièrement l'identification d'épitopes T dans l'entérotoxine staphylococcique B. L'invention concerne également des peptides d'épitopes T dérivés de l'entérotoxine staphylococcique B à l'aide desquels il est possible de créer des variants modifiés de l'entérotoxine staphylococcique B présentant une immunogénécité réduite.

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