Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide...

Details Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide... Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide...

C - Chemistry, Metallurgy

07

C

C07C 233/65 (2006.01) A61K 31/165 (2006.01) A61K 31/445 (2006.01) C07D 211/26 (2006.01)

Patent

CA 2555890

Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues are provided, of the formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivoor in vitro,and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues arylamide d'acide biphényl-4-carboxylique hétéroalkyle substitué de formule (I). Dans cette formule, les variables sont décrites dans la description. De tels composés sont des ligands pouvant être utilisés pour moduler l'activité d'un récepteur spécifique <i>in vivo </i>ou<i> in vitro</i>, et sont particulièrement utiles pour traiter des troubles associés à l'activation d'un récepteur pathologique chez les humains, chez les animaux domestiques et chez le bétail. L'invention concerne des compositions pharmaceutiques et des méthodes pour utiliser des tels composés pour traiter de tels troubles, ainsi que des méthodes pour utiliser de tels ligands destinés à des études de localisation de récepteur.

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