Method for synthesising heterocyclic compounds from thiourea...

Details Method for synthesising heterocyclic compounds from thiourea... Method for synthesising heterocyclic compounds from thiourea...

C - Chemistry, Metallurgy

07

D

C07D 233/50 (2006.01) C07D 235/30 (2006.01) C07D 265/08 (2006.01) C07D 265/18 (2006.01) C07D 277/18 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2526646

The invention relates to a method illustrated in model 1 for synthesising heterocyclic compounds of formula (I). According to said method, isothiocyanate of formula (II) is reacted with the primary amine of formula (III) to obtain thiourea of formula (IV). The thiourea of formula (IV) is then converted into the heterocycle of formula (I) using a base and a sulfonic acid.

Procédé illustré par le schéma 1, pour la synthèse de composés hétérocycliques de formule (I). Selon ledit procédé, l'isothiocyanate de la formule (II) est d'abord mis en réaction avec l'amine primaire de la formule (III) pour obtenir de la thiourée de formule (IV). La thiourée de formule (IV) est alors convertie à l'aide d'une base et d'un chlorure d'acide sulfonique en hétérocycle de formule (I).

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