Fucosyltransferase genes and uses thereof

Details Fucosyltransferase genes and uses thereof Fucosyltransferase genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 14/705 (2006.01) C12N 9/10 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2223440

Purified DNA encoding .alpha.(1,3)fucosyltransferase and the recombinant proteins expressed from such DNA are disclosed. The recombinant fucosyltransferase polypeptides are used to fucosylate proteins to produce therapeutics useful for the treatment of disease, e.g., an adverse immune reaction such as septicemia or septic shock.

L'invention porte sur de l'ADN purifié codant la .alpha.(1,3)fucosyltransférase et les protéines de recombinaison exprimées à partir de cet ADN. On utilise les polypeptides de fucosyltransférase de recombinaison pour fucosyler les protéines et fabriquer des médicaments utiles pour le traitement de maladies, comme par exemple, des réactions immunitaires indésirables telles que la septicémie ou le choc septique.

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