A method of improving efficacy of biological...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/52 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2528458

Disclosed is a protein variant which substitutes valine for phenylalanine residue in a binding domain having a biological response-modifying function by binding to a receptor, ligand or substrate. Also, the present invention discloses a DNA encoding the protein variant, a recombinant expression vector to which the DNA is operably linked, a host cell transformed or transfected with the recombinant expression vector, and a method of preparing the protein variant comprising cultivating the host cell and isolating the protein variant from the resulting culture. Further, the present invention discloses a pharmaceutical composition comprising the protein variant and a pharmaceutically acceptable carrier.

L'invention concerne une variante génétique de protéine qui remplace un résidu phénylalanine par une valine dans un domaine de liaison comportant une fonction de modification de la réponse biologique par liaison à un récepteur, à un ligand ou à un substrat. L'invention concerne aussi l'ADN codant pour la variante génétique de protéine, un vecteur d'expression recombiné auquel cet ADN est lié de façon opérationnelle, une cellule hôte transformée ou transfectée à l'aide du vecteur d'expression recombiné, ainsi qu'un procédé d'élaboration de ladite variante qui comporte les étapes consistant à mettre en culture la cellule hôte et à isoler la variante de la culture obtenue. L'invention se réfère de plus à une composition pharmaceutique comprenant cette variante et un excipient pharmaceutiquement acceptable.

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