Protease for activating clotting factor vii

Details Protease for activating clotting factor vii Protease for activating clotting factor vii

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 38/43 (2006.01) A61L 15/38 (2006.01) C07K 14/745 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/573 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2269109

A protease for activating the blood clotting factor VII and its proenzyme is described. Moreover, a process for obtaining the protease and its use in hemorrhage prophylaxis or hemostasis is described. A stabilized factor V and a stabilized factor VIII preparation are furthermore described which are free of the inactive factor VIII fragments formed by proteolytic degradation as a result of the inhibition or the removal of the protease activating the blood clotting factor VII. Moreover, a test system for the qualitative and quantitative detection of a protease which activates the blood clotting factor VII is described. Finally, pharmaceutical preparations are described which are suitable for the prophylaxis and treatment of bleeding events, e.g. in the presence of FVIII inhibitors, wound healing and for the treatment of disorders which are caused by fibrin-containing thrombin. The preparations contain the protease activating the blood clotting factor 'VII, or its proenzyme.

L'invention porte sur une protéase permettant d'activer le facteur VII, un facteur de coagulation, et sa proenzyme. En outre, un procédé servant à obtenir la protéase et son utilisation pour prévenir les hémorragies ou l'hémostase sont décrits. L'invention concerne également un facteur V stabilisé et une préparation de facteur VIII stabilisée, qui sont exempts de fragments de facteur VIII inactif formés par la dégradation protéolytique, grâce à l'inhibition ou à l'élimination de la protéase activant le facteur VII. En outre, un système d'analyse servant à détecter qualitativement et quantitativement une protéase qui active le factor VII est décrit. Enfin, l'invention a aussi trait à des préparations pharmaceutiques destinées à la prévention et au traitement des saignements, p. ex. en présence d'inhibiteurs du facteur VIII, guérison des plaies, et pour traitement d'affections causées par de la thrombine contenant de la fibrine. Les préparations contiennent la protéase activant le facteur VII ou sa proenzyme.

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