Use of benzylidene-malononitrile derivates for the treatment...

A - Human Necessities – 61 – K

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A61K 31/275 (2006.01)

Patent

CA 2187752

The present invention relates to products and methods useful for treating leukemia, in particular acute lymphoblastomic leukemias. Compounds described herein are effective in inhibiting activities associated with ALL both in vitro and in vivo. Methods for modifying such compounds and screening other compounds are also provided in order to identify additional compounds with similar or better inhibition properties.

La présente invention concerne des produits et des méthodes utiles pour traiter des leucémies, en particulier les leucémies lymphoblastiques aiguës. Les composés décrits ici sont efficaces pour inhiber les effets observés dans les leucémies lymphoblastiques aiguës, aussi bien in vivo que in vitro. L'invention concerne également des méthodes pour modifier de tels composés et pour cribler d'autres composés, afin d'identifier des composés additionnels avec des propriétés d'inhibition similaires ou améliorées.

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