Cholesteryl ester transfer protein inhibitors

A - Human Necessities – 61 – K

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A61K 31/5375 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2635087

Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), A1 is a cyclic group, and B is a cyclic group which is attached to the heterocyclic ring directly or through a methylene group.

Des composés à structure de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, sont des inhibiteurs de CETP qui s'avèrent utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL, traiter ou prévenir l'athérosclérose. Dans les composés de formule (I), A1 et B sont des groupes cycliques, B étant lié au noyau hétérocyclique directement ou par un groupe méthylène.

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