Use of gabapentin in the treatment of anxiety and panic

Details Use of gabapentin in the treatment of anxiety and panic Use of gabapentin in the treatment of anxiety and panic

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/22 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2193384

The instant invention is novel uses of known cyclic amino acids. Such compounds as gabapentin are useful in the treatment of anxiety and in the treatment and/or prevention of panic attacks. The partial N-terminal sequence of the gabapentin binding protein has been determined to be identical to the N- terminal sequence of the mature .alpha.2.delta. subunit of the L-type Ca2+ channel from rabbit skeletal muscle.

La présente invention concerne des utilisations nouvelles d'amino-acides cycliques connus. Des composés tels que la gabapentine sont utiles dans le traitement de l'anxiété et dans le traitement et/ou la prévention des accès de panique. Il a été déterminé que la séquence partielle N-terminale de la protéine de liaison de la gabapentine est identique à la séquence N-terminale de la sous-unité .alpha.¿2?.delta. mature du canal calcique de type L des muscles squelettiques du lapin.

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