A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 24/06 (2006.01) A61L 24/00 (2006.01) C09J 4/00 (2006.01)
Patent
CA 2247906
A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt.% to 16 wt.% of the composition; and (C) at least one acidic stabilizing agent having a pK a ionization constant of from about 0 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces.
Une composition de monomères biocompatible comprend: (A) au moins un monomère formant un polymère acceptable sur le plan médical; (B) au moins un agent plastifiant présent dans la composition en une quantité comprise entre 0,5 et 15 % en poids; (C) au moins un agent stabilisant acide ayant une constante d'ionisation pKa comprise entre environ 1 et environ 7. On peut appliquer la composition à diverses matières et elle est particulièrement adaptée en tant qu'adhésif tissulaire in vivo. Un procédé d'union in vivo de deux surfaces, par exemple de tissus corporels consiste (a) à maintenir ensemble les bords de tissu abîmé afin de former des surfaces tissulaires en aboutement; (b) à appliquer aux surfaces tissulaires en aboutement une dose excessive d'une composition contenant 1) au moins un monomère, lequel forme un polymère biodégradable acceptable sur le plan médical, 2) au moins un agent plastifiant, et 3) au moins un agent stabilisant acide; et (c) à maintenir les surfaces en contact jusqu'à ce que la composition polymérise pour former un film épais de composition polymérisée pontant les surfaces tissulaires en aboutement.
Clark Jeffrey G.
Leung Jeffrey C.
Closure Medical Corporation
Smart & Biggar
LandOfFree
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