Novel compounds

Details Novel compounds Novel compounds

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2231015

HGBAB90 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HGBAB90 polypeptides and polynucleotides in the design of protocols for the treatment of pulmonary emphysema, arthritis, multiple sclerosis, periodontal disease, cystic fibrosis, respiratory disease, thrombosis, cancer, cachexia, angina, glaucoma, inflamatory disorders, osteoporosis, cardiovascular disorders such as hypertension, atherosclerotic disorders such as cardiac infarction, and stroke, asthma, psoriasis, chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, demyelinating diseases, AIDS immune deficiency, disorders of photoreceptor degeneration, and lens cataract formation, organ transplant rejection, cataracts, restenosis, muscular dystrophy, renal failure, cerebral vasospasm, pancreatitis, and diabetic nephropathy, among others, and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides HGBAB90, ainsi que de méthodes de production de tels polypeptides par des techniques de recombinaison. Des méthodes sont également dévoilées pour utiliser les polypeptides et les polynucléotides HGBAB90 dans la conception de protocoles pour le traitement de l'emphysème pulmonaire, de l'arthrite, de la sclérose en plaques, de la parodontopathie, de la fibrose kystique, de la maladie respiratoire, de la thrombose, du cancer, de la cachexie, de l'angine, du glaucome, des troubles inflammatoires, de l'ostéoporose, des troubles cardio-vasculaires comme l'hypertension, les troubles athérosclérotiques comme l'infarctus du myocarde et l'accident cérébro-vasculaire, l'asthme, le psoriasis, les maladies neurodégénératives chroniques comme les maladies démyélinisantes d'Alzheimer, de Parkinson et de Huntington, le syndrome d'immunodéficience acquise (SIDA), les troubles liés à la dégénérescence des photorécepteurs et la formation des cataractes lenticulaires, le rejet d'organes greffés, les cataractes, la resténose, la dystrophie musculaire, l'insuffisance rénale, les spasmes des vaisseaux du cerveau, la pancréatite et la néphropathie diabétique, entre autres, ainsi que des épreuves diagnostiques pour ces affections.

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