Uses of nicotinamide adenine dinucleotide and its analogs...

A - Human Necessities – 61 – K

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A61K 31/7084 (2006.01) A61K 31/66 (2006.01) A61K 31/7052 (2006.01) A61K 31/706 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2302687

This invention provides a method of killing tumor cells or microorganisms which comprises contacting the tumor cells or the microorganisms with an amount of nicotinamide adenine dinucleotide (NAD) or its analogs effective to increase clonogenic toxicity of cells. This invention also provides a method of killing tumor cells or microorganisms in a subject which comprises administering an amount of nicotinamide adenine dinucleotide or its analogs effective to increase clonogenic toxicity of cells to the subject.

La présente invention concerne un procédé permettant de tuer des cellules tumorales ou des micro-organismes, lequel procédé consiste à mettre les cellules tumorales ou les micro-organismes en contact avec une quantité efficace de nicotinamide adénine dinucléotide (NAD) ou de ses analogues dans le but d'augmenter la toxicité clonogénique des cellules. La présente invention concerne également un procédé permettant de tuer des cellules tumorales ou des micro-organismes chez un sujet, lequel procédé consiste à administrer au sujet une quantité efficace de nicotinamide adénine dinucléotide ou de ses analogues dans le but d'augmenter la toxicité clonogénique des cellules.

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