Process for the preparation of .beta.-hydroxyketones

C - Chemistry – Metallurgy – 07 – C

Patent

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260/576, 260/580

C07C 45/56 (2006.01) C07C 49/17 (2006.01) C07C 49/245 (2006.01)

Patent

CA 2006340

ABSTRACT OF THE INVENTION A process for the preparation of .beta.-hydroxyketones comprising the catalytic hydrogenolysis of an aqueous solution of isoxazolines having the formula Image in a fixed bed reactor containing a transition metal catalyst at a temperature between 20 to 150°C and a pressure from about 0 to 150 psig; wherein R1 and R2 are independently selected from hydrogen, alkyl, cycloalkyl or aromatic group and wherein the aqueous solution of isoxazolines is substantially free of acids or buffers.

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