C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/12 (2006.01) C07H 21/04 (2006.01) C07K 14/18 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2443323
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.
L'invention concerne des acides nucléiques isolés contenant des unités transcriptionnelles codant pour une séquence signal d'un flavivirus et un antigène de flavivirus immunogène d'un second flavivirus ou d'un antigène de flavivirus immunogène chimérique comprenant une séquence de plus d'un flavivirus. L'invention concerne également un vaccin d'acide nucléique et de protéine, ainsi que l'utilisation de ce vaccin pour immuniser un sujet contre des infections à flavivirus. Cette invention concerne également des antigènes codés par les acides nucléiques de cette invention, des anticorps produits en réponse à ces antigènes, ainsi que l'utilisation de ces antigènes et/ou anticorps pour la détection de flavivirus ou le diagnostic d'une infection à flavivirus.
Centers For Disease Co The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
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