Method of ophthalmic drug delivery

Details Method of ophthalmic drug delivery Method of ophthalmic drug delivery

A - Human Necessities

61

K

A61K 33/42 (2006.01) A61K 9/00 (2006.01) A61K 31/4178 (2006.01) A61K 33/06 (2006.01) A61K 33/10 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2129635

A method for prolonged delivery of a therapeutic agent to the eye is disclosed. The method provides for the addition of a desired drug to a suitable, preferably non-aqueous carrier. An amount of the carrier containing the therapeutic dose of the drug is placed on the skin exterior to the ocular surface near the lateral and lower lid margins. Movements of the orbicularis oculi associated with the scissor-like closing of the lids of the eye continuously transport small portions of the therapeutic agent and carrier into the interpalpebral space where the drug is released to the corneal surface. Further provided is a calcium-based ophthalmic composition which is particularly effective treating dry eye syndrome and which is optimally delivered by the method just described.

L'invention se rapporte à un procédé destiné à prolonger l'administration d'un agent thérapeutique dans l'oeil. Le procédé consiste à ajouter un médicament désiré à un excipient approprié, de préférence non aqueux. Une quantité de l'excipient contenant la dose thérapeutique de médicament est placée sur la peau à l'extérieur de la surface oculaire, près des bords latéraux et inférieurs des paupières. Les mouvements du muscle orbiculaire associés à ceux des paupières qui se ferment à la manière de ciseaux transportent en continu de petites quantités de l'agent thérapeutique et de l'excipient dans la sphère interpalpébrale où le médicament est libéré sur la surface cornéenne. L'invention se rapporte également à une composition ophtalmique à base de calcium qui est particulièrement efficace pour traiter le syndrome de l'oeil sec et qui est administré de façon optimale par le procédé décrit.

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