C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2278303
The invention relates to a method for indicating groups at risk of cardiovascular diseases. In particular, the invention offers the possibility of determining whether a person, by smoking, has an increased risk of cardiovascular disease on the basis of a genetic predisposition. A polymorphism has now been found which is clearly associated with an increased risk of cardiovascular disease in smokers in contrast to non-smokers. Smokers who possess a specific allele are at appreciably greater risk than smokers who do not possess this allele.
La présente invention se rapporte à un procédé permettant de repérer des groupes à risque s'agissant de contracter des maladies cardio-vasculaires. L'invention offre notamment la possibilité d'évaluer si une personne, qui fume, présente un risque accru de contracter une maladie cardio-vasculaire, sur la base d'une prédisposition génétique. On a découvert un polymorphisme qui est clairement associé à un risque accru de maladie cardio-vasculaire chez les fumeurs par rapport aux non fumeurs. Les fumeurs qui possèdent un allèle spécifique présentent un risque sensiblement supérieur que les fumeurs qui ne possèdent pas cet allèle.
Grobbee Diederick Egbertus
Kluft Cornelis
Mccarthy Tetrault Llp
Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk On
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