Immunostimulatory compositions and methods

Details Immunostimulatory compositions and methods Immunostimulatory compositions and methods

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2632663

The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjuagte that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimultory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.

L'invention concerne des conjugués comprenant un polypeptide co-stimulatoire immun et un antigène ou un agent infectieux. Les conjugués sont utiles pour la génération ou l'amélioration d'une réponse immune contre l'antigène ou l'agent infectieux. L'invention concerne également des cellules immunes modifiées au moyen d'un conjugué, ces cellules étant utiles pour la génération ou l'amélioration d'une réponse immune contre un antigène ou un agent infectieux. L'invention concerne également des fractions immunostimulatoires comprenant un polypeptide co-stimulatoire immun, ces fractions étant utiles pour stimuler une réponse immune. L'invention concerne également des méthodes d'immunothérapie et des méthodes de traitement ou de prévention d'infections.

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