Substituted tricyclic heteroaryl compounds as janus kinase...

Details Substituted tricyclic heteroaryl compounds as janus kinase... Substituted tricyclic heteroaryl compounds as janus kinase...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2673038

The present invention provides substituted tricyclic heteroaryl compounds, including, for example, pyridoindoles, pyrimidinoindoles and triazinoindoles that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases such as immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

La présente invention concerne des composés hétéroaryliques tricycliques substitués comprenant, par exemple, des pyridoindoles, des pyrimidinoindoles et des triazinoindoles, lesquels modulent l'activité des Janus kinases et sont utiles dans le traitement de maladies liées à l'activité des Janus kinases telles que des maladies liées au système immunitaire, des troubles de la peau, des troubles myélo-prolifératifs, un cancer et d'autres maladies.

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