Therapeutic monoclonal antibodies that neutralize botulinum...

Details Therapeutic monoclonal antibodies that neutralize botulinum... Therapeutic monoclonal antibodies that neutralize botulinum...

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 6/00 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/33 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2492883

This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

L'invention concerne des anticorps qui se lient spécifiquement et neutralisent une neurotoxine botulique de type A (BoNT/A) ainsi que les épitopes liés par ces anticorps. Ces anticorps ainsi que des dérivés de ceux-ci et/ou d'autres anticorps qui se lient spécifiquement aux épitopes neutralisants de cette invention peuvent être utilisés pour neutraliser une neurotoxine botulique et sont par conséquent utiles dans le traitement du botulisme.

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