Test system and method for the detection of analytes

Details Test system and method for the detection of analytes Test system and method for the detection of analytes

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2554848

The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a probe, preferably a nucleic acid or a nucleic acid derivative, coupled to a catalytic component, preferably an enzyme. The analyte induces a conformation change in the probe, which alters the accessibility for a substrate in the probe to catalytic components and the change in substrate turnover, corresponding to the change in catalytic activity, is measured.

L'invention concerne des systèmes de test analytique et des procédés d'analyse faisant appel à des commutateurs moléculaires pour déterminer des analytes de manière qualitative et quantitative dans un échantillon, et dont le champ d'application est large si le choix du commutateur moléculaire est adapté aux analytes. Le commutateur moléculaire est constitué d'une sonde formée de préférence d'acide nucléique ou d'un dérivé d'acide nucléique et accouplée avec un composant catalytique, de préférence une enzyme. L'analyte entraîne un changement dans la conformation de la sonde, ce qui modifie l'accès aux composants catalytiques pour un substrat se trouvant dans l'échantillon, et la modification de la transformation du substrat, qui correspond au changement de l'activité catalytique, est mesurée.

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