Phospholipase c homolog

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) A61K 31/70 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216858

The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleotide sequences or antibodies specific for PLCH.

Séquences de nucléotides et d'acides aminés identifiant et codant un nouvel homologue de phospholipase C (plch et PLCH). La présente invention concerne également des molécules antisens des séquences de nucléotides de plch, des vecteurs d'expression pour la production de PLCH purifié, des anticorps capables de se lier spécifiquement au PHLC, des sondes d'hybridation ou des oligonucléotides permettant de détecter les séquences de nucléotides codant le PLCH surnuméraire, des cellules hôtes produites par génie génétique pour l'expression de PLCH, des tests de diagnostic visant les cellules et/ou les tissus activés, enflammés, maladifs, et résistant à l'hydroxyurée sur la base des séquences de nucléotides codant le PLCH ou des anticorps spécifiques du PLCH.

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