Use of green porphyrins in the manufacture of a medicament...

A - Human Necessities – 61 – K

Patent

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Details

A61K 41/00 (2006.01) A61K 9/127 (2006.01) A61K 31/40 (2006.01) A61K 31/409 (2006.01)

Patent

CA 2257564

A method to prevent or inhibit the development of arterial plaque, comprising the steps of: (a) administering to a subject an amount of a green porphyrin compound effective to prevent or inhibit said development; and (b) allowing the inhibition to occur in the absence of irradiation with light absorbed by the green porphyrin; or a pharmaceutical composition for preventing or inhibiting the development of arterial plaque. The composition comprises: (a) an amount of a green porphyrin compound effective to prevent or inhibit the development when administered to a subject in need of such treatment, even in the absence of irradiaton with light absorbed by said green porphyrin; and (b) a pharmaceutically acceptable excipient. The administration of the green porphyrin need not be accompanied by any purposeful irradiation with light.

L'invention concerne un procédé de prévention ou d'inhibition du développement de la plaque artérielle, procédé comprenant les étapes consistant à: a) administrer à un sujet une quantité d'un composé de porphyrine verte, efficace dans la prévention ou l'inhibition de ce développement; b) permettre l'inhibition en l'absence d'irradiation avec de la lumière absorbée par la porphyrine verte. L'invention concerne également une composition pharmaceutique utilisée dans la prévention ou l'inhibition du développement de la plaque artérielle. Cette composition comprend: a) une quantité d'un composé de porphyrine verte efficace pour prévenir ou inhiber ce développement lorsqu'elle est administrée à un sujet nécessitant ce traitement, même en l'absence d'irradiation avec de la lumière absorbée par la porphyrine verte; et b) un excipient pharmaceutiquement acceptable. Il n'est donc pas nécessaire de faire suivre l'administration de la porphyrine verte d'une irradiation intentionnelle avec de la lumière.

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