C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/44 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2078814
This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula (See Formula I) wherein Q is S, N or NR2; Y is CH, N or NR2; R1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonyl-aminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; R2 is hydrogen or loweralkyl; R3 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen; and n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful in the treatment of memory dysfunctions characterized by a chalinergic deficit such as the type associated with Alzheimer's disease and other memory disorders. Compounds of this invention also have utility as modulators of neurotransmitter function such as noradrenergic and serotonergic and as such are useful for treatment of depression and personality disorders such as obsessive compulsive disorders. Additionally, compounds of this invention are useful as topical antiinflammatory agents for the treatment of various dermatoses.
Effland Richard C.
Klein Joseph T.
Martin Lawrence L.
Aventisub II Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst-Roussel Pharmaceuticals Inc.
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