Pharmaceutical compositions comprising of arsenous acid, its...

A - Human Necessities – 61 – K

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A61K 33/36 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2608035

The present application relates to pharmaceutical compositions and methods for treatment of urogenital diseases and bone metastasis in a human, which pharmaceutical composition contains an effective amount of arsenous acid alkaline or earth alkaline metal salt and/or a pharmaceutically acceptable adjuvant. According to the present invention, the alkaline arsenous acid metal salt is sodium meta-arsenita(AsO2Na) or potassium meta-arsenite(AsO2K). The effective amount of arsenous acid alkaline or earth alkaline metal salt is 0.0001-1500 mg/kg, preferably 1-1000 mg/kg, more preferably 1-150 mg/kg, and most preferably 50-100 mg/kg of body weight/day. The administration form of the pharmaceutical compositions of the invention is preferably oral, such as a tablet, capsule, powder and/or solution with a pharmaceutically acceptable carrier, diluent or excipient.

La présente invention concerne décomposition pharmaceutique des procédés destinés au traitement de maladie bureaux génitales et aux métastases osseuses chez un humain, cette composition pharmaceutique contenant une quantité efficace d'un alcalin acide arsénieux ou de sels métalliques alcalins de terre et/ou d'un adjuvant répondant aux normes pharmaceutiques. Selon cette invention, le sel métallique d'acide alcalin est sodium méta-arsenita(AsO2#191Na) ou potassium meta-arsenite(AsO2#191K). La quantité efficace d'alcalin acide arsénieux ou de sels métalliques alcalins de terre est comprise entre 0,0001 et 1500 mg/kg, de préférence entre 1 et 1000 mg/kg, mieux, entre 1 et 150 mg/kg et encore mieux entre 50 et 100 mg/kg du poids du corps par jour. La forme d'administration de ces compositions pharmaceutiques est de préférence orale, telle qu'un cachet, une gélule, de la poudre et/ou une solution avec un porteur, un diluant ou un excipient répondant aux normes pharmaceutiques.

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