Pharmaceutical agents for the treatment of myocardial...

Details Pharmaceutical agents for the treatment of myocardial... Pharmaceutical agents for the treatment of myocardial...

A - Human Necessities

61

K

A61K 31/405 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2143544

This invention relates to the use of certain 3- substituted 2-oxindole-1-carboxamides of the formula: Image (I) (wherein X is H, halogen, alkyl, alkoxy, alkylthio, CF3, alkylsulfonyl, nitro, phenyl, alkanoyl, benzoyl, thenoyl, alkanamido, benzamido or dialkylsulfamoyl; Y is H, halogen, alkyl, cycloalkyl, alkoxy, alkylthio or CF3, or X and Y, together with carbon atoms to which they are attached, form a ring, R1 is alkyl, cycloalkyl, cycloalkenyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenoxyalkyl, thiophenoxyalkyl, naphthyl, etc. n is 0, 1 or 2, Q is a divalent cyclic radical, and R ? is H, halogen or alkyl) and their pharmaceutically acceptable base salts for the treatment or prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury in mammals, including humans.

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