Multiple variants of meningococcal protein nmb1870

Details Multiple variants of meningococcal protein nmb1870 Multiple variants of meningococcal protein nmb1870

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2507009

Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti- meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixtures comprising different variants of NMB 1870.

L'invention concerne la protéine NMB1870 méningococcique décrite dans la technique antérieure. Selon les inventeurs, NMB 1870 possède un antigène efficace pour déclencher des réponses d'anticorps anti-méningococciques, et ce dernier est exprimé dans tous les sérogroupes méningococciques. Quarante-deux séquences de NMB 1870 différentes ont été identifiées, et ces groupes ont classés en trois variants. Du sérum dirigé contre un variant donné est bactéricide dans le même groupe de variants, mais n'est pas actif contre les souches qui expriment un des deux autres variants, c'est-à-dire qu'il y a une protection croisée intra-variants mais pas de protection croisée inter-variants. En vue d'une efficacité de souche croisée maximale, l'invention utilise donc des mélanges contenant différents variants de NMB 1870.

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