C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2377479
Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 agonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1 to LFA-1. The ICAM-1 agonist/antagonists may be applied to mucosal surfaces, on or in contraceptive devices or in oral solutions such as breast milk supplements and infant formula.
L'invention porte sur des procédés, compositions et articles bloquant la transmission transépithéliale du VIH, en recourant à des agonistes/antagonistes de l'ICAM-1. Lesdits agonistes/antagonistes de l'ICAM-1 bloquent la transmission du virus sur son site d'exposition. Ce blocage ne nécessite pas celui de la fixation de l'ICAM-1 sur le LFA-1. Les agonistes/antagonistes de l'ICAM-1 peuvent s'appliquer à la surface de muqueuses, sur ou dans des dispositifs contraceptifs, ou dans des solutions orales tels que des compléments du lait maternel et des préparations pour nourrissons.
Khanna Kristen V.
Markham Richard B.
Smart & Biggar
The Johns Hopkins University
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