A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2608476
Preparations for controlling intraocular pressure in the eye comprise as an active compound, arylazine substituted with a carbonylic moiety, which compound is capable of effecting a "pharmacological trabeculocanalotomy" in an eye by means of reducing juxtacanalicular meshwork to promote outflow of aqueous. The organic active compound increases Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for glaucoma, e.g., primary open angle glaucoma.
Cette invention concerne des préparations destinées à contrôler la pression intraoculaire de l~AEil comprenant, en tant queprincipe actif, l~arylazine substituée par une portion carbonylique. Ledit principe actif est capable d~effectuer une "trabéculocanalotomie pharmacologique" dans un AEil en réduisant le maillage juxtacanaliculaire pour faciliter l~écoulement vers l~extérieur de l~humeur aqueuse. Le principe actif organique accroît l~activité de la gélatinase A dans les cellules oculaires en augmentant l~expression membranaire cellulaire des métalloprotéinases matricielles de type membranaire (MT-MMP) afin d~augmenter l~écoulement vers l~extérieur d~humeur aqueuse. Ces préparations sont utiles dans le traitement du glaucome, , tel le glaucome primaire à angle ouvert par exemple.
Bartels Stephen
Flick Rosemarie
Pfeffer Bruce A.
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
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