C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2438827
The present invention relates to an isolated retinoid inducible serine carboxypeptidase proteins or polypeptides, and the nucleic acid molecules encoding such a protein or polypeptide. Nucleic acid constructs, expression systems and host cells containing those nucleic acid molecules, and antibodies raised against the proteins or polypeptides are also disclosed. The present invention also relates to methods for detecting a vascular disease or disorder, inhibiting smooth muscle cell growth, treating vascular hyperplasia, and inhibiting the activity of extracellular regulated kinase. The present invention also relates to a transgenic non-human animal lacking a gene encoding a retinoid inducible protein or polypeptide.
L'invention concerne des protéines ou des polypeptides isolés de carboxypeptidase de sérine inductibles par un rétinoïde et les molécules d'acides nucléiques codant de telles protéines ou de tels polypeptides. L'invention concerne également des constructions d'acides nucléiques, des systèmes d'expression et des cellules hôtes renfermant ces molécules d'acides nucléiques, ainsi que des anticorps dirigés contre les protéines ou polypeptides. L'invention concerne en outre des méthodes de détection d'une maladie ou d'un trouble vasculaire, inhibant une croissance cellulaire des muscles lisses, traitant une hyperplasie vasculaire et inhibant l'activité d'une kinase régulée extracellulaire. L'invention concerne enfin un animal non humain transgénique exempt d'un gène codant une protéine ou un polypeptide inductible par un rétinoïde.
Chen Jiyuan
Miano Joseph Michael
Streb Jeffrey William
Gowling Lafleur Henderson Llp
University Of Rochester
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