Pharmaceutical composition for the improvement of dysuria

A - Human Necessities – 61 – K

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A61K 31/52 (2006.01)

Patent

CA 2084962

HOE 91/S 036 Abstract Pharmaceutical compositions for the improvement of dysuria comprising a pharmaceutical carrier and a therapeuti- cally effective amount of a xanthine derivative represented by the general formula I Image I wherein R1 denotes a group of the formula R4-CO- or R5R6(OH)C- or a carboxyl group, wherein R4 and R5 independently denote an alkyl group having 1-3 carbon atoms, and R6 denotes a hydrogen atom or an alkyl group having 1-3 carbon atoms, R2 denotes a hydrogen atom, an alkyl group having 1-5 carbon atoms or an alkyloxy group having 1-5 carbon atoms, R3 denotes an alkyl group having 1-3 carbon atoms and n denotes 1-6 or a pharma- ceutically acceptable acid addition salt thereof. They are active in prolonging urination intervals and increasing urination threshold pressure with almost no influence upon constrictive force of the bladder. Thus, they are effective in treatment and prevention of dysuria such as pollakiuria and incontinence of urine.

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