Glycopeptides and methods of making and using them

Details Glycopeptides and methods of making and using them Glycopeptides and methods of making and using them

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/04 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2716622

In one embodiment, the invention provides glycopeptides (or carbohydrate-peptide conjugates) comprising TACAs that direct against (e.g., bind specifically to) cytotoxic T lymphocytes (CTLs) or helper T cells for, e.g., CTL- or T-helper-based immunotherapy of carcinomas, and methods for making and using the glycopeptides of the invention. In one embodiment, the invention provides novel glycopeptides comprising tumor-derived carbohydrate or tumor-derived epitopes that specifically bind to major histocompatibility (MHC) class I molecules on cytotoxic T lymphocytes (CTLs) or MHC molecules on helper T cells, and methods for using same, e.g., as a vaccine, including a pan-cancer vaccine.

Linvention concerne, dans un mode de réalisation, des glycopeptides (ou conjugués glucide-peptide) qui comportent des TACA qui se dirigent contre (par exemple se lient spécifiquement à) des lymphocytes T cytotoxiques (CTL) ou des lymphocytes T auxiliaires pour, par exemple, une immunothérapie de carcinomes à base de CTL ou dauxiliaire T, et des procédés de préparation et dutilisation des glycopeptides de linvention. Dans un mode de réalisation, linvention concerne de nouveaux glycopeptides qui comportent un glucide dérivé de tumeur ou des épitopes dérivés de tumeur qui se lient spécifiquement aux molécules de classe I dhistocompatibilité majeure (MHC) sur des molécules de lymphocytes T cytotoxiques (CTL) ou MHC sur lymphocytes T auxiliaires, et procédés dutilisation de ces derniers, comme vaccin, comprenant un vaccin anticancéreux.

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