A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 31/4422 (2006.01)
Patent
CA 2691752
The present invention relates to the formulation of solid dosage forms comprising a therapeutically effective amount of a dihydropyridine calcium channel antagonist such as Lercanidipine or salt thereof, in combination with colloidal silicon dioxide such as Aerosil.TM. to enhance bioavailability and improve solubility, and a process for the preparation thereof by wet granulation.
La présente invention porte sur la formulation de formes posologiques solides comprenant une quantité thérapeutiquement efficace d'un antagoniste des canaux calciques de type dihydropyridine, tels que la Lercanidipine ou un sel de celle-ci, en combinaison avec du dioxyde de silicium colloïdal tel que l'Aerosil pour augmenter la biodisponibilité et améliorer la solubilité. L'invention porte également sur un procédé pour la préparation de ces formes posologiques par granulation par voie humide.
Karavas Evangelos
Koutri Ioanna
Koutris Efthimios
Stathaki Eleni
Dimock Stratton Llp
Pharmathen S.a.
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