C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/38 (2006.01) A61K 31/381 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2716679
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 .beta.-hydroxysteroid dehydrogenase type 1(11 .beta.- HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 .beta.- hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 .beta.-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.
La présente invention concerne généralement le domaine des composés thérapeutiques. La présente invention concerne plus spécifiquement certains composés amido-thiophène qui, entre autres, inhibent la 11 ß-hydroxystéroïde déshydrogénase de type 1 (11 ß-HSD1 ). La présente invention concerne également des compositions pharmaceutiques comprenant ces composés, et l'utilisation de ces composés et de ces compositions, in vitro et in vivo, pour inhiber la 11 ß-hydroxystéroïde déshydrogénase de type 1; pour traiter les troubles qui sont améliorés par l'inhibition de la 11 ß-hydroxystéroïde déshydrogénase de type 1; pour traiter le syndrome métabolique, qui comprend des troubles tels que le diabète de type 2 et l'obésité, et les troubles associés comprenant l'insulinorésistance, l'hypertension, les troubles lipidiques et les troubles cardiovasculaires tels que la cardiopathie ischémique (maladie coronarienne); pour traiter les troubles du SNC tels que le trouble cognitif modéré et la démence précoce, y compris la maladie d'Alzheimer; etc.
Dyke Hazel Joan
Pallin Thomas David
Perrior Trevor Robert
Seckl Jonathan Robert
Walker Brian Robert
Kirby Eades Gale Baker
The University Of Edinburgh
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