Nucleosides and oligonucleotides having 2'-ether groups

Details Nucleosides and oligonucleotides having 2'-ether groups Nucleosides and oligonucleotides having 2'-ether groups

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2147798

Compounds of the formula Image wherein R1 and R2 are each independently of the other hydrogen or a protecting group, or R1 has those meanings and R2 is a radical forming a phosphorus-containing nucleotide bridge group; B is a purine or pyrimidine radical or an analogue thereof; and R3 is OH, F or (CF2)n CF3 wherein n is a number from 0 to 7, and oligonucleotides that comprise those nucleosides are described.

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