Technique for stabilization of yw753 reparation

Details Technique for stabilization of yw753 reparation Technique for stabilization of yw753 reparation

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/08 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/16 (2006.01) A61K 47/20 (2006.01) A61K 47/34 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2618439

[PROBLEMS] To provide an injection preparation which comprises a depsipeptide having a disulfide bond in the molecule, can be prepared in a simple manner, and is stable. [MEANS FOR SOLVING PROBLEMS] An injection preparation having an excellent long-term stability which can be prepared by replacing a solution containing a substance such as ferric chloride and having a pH value ranging from 7.0 to 1.0 inclusive, by nitrogen gas a solution, by nitrogen. [ADVANTAGES] The injection preparation is expected to be free from the formation of any aggregation or cluster of a depsipeptide having a double bond in the molecule and be excellent in storage stability.

La présente invention concerne une préparation d~injection comprenant un depsipeptide dont la molécule comporte une liaison bisulfure, pouvant être préparée de manière simple, et étant stable. La présente invention consiste en une préparation d'injection présentant une excellente stabilité à long terme, pouvant être préparée en remplaçant une solution, contenant une substance telle que du chlorure ferrique et ayant une valeur de pH comprise entre 7,0 et 1,0 inclus, par de l~azote. Cette préparation d~injection présente les avantages de ne pas avoir tendance à la formation d'agrégats ou de groupes de depsipeptides dont la molécule comporte une liaison disulfide, et d~avoir une excellente stabilité au stockage.

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