Use of flagellin in the immunotherapy of yersinia pestis

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 38/00 (2006.01) A61K 39/02 (2006.01) A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2589553

The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against Yersinia pestis.

L'invention concerne une protéine hybride comprenant de la flagelline comme adjuvant et un antigène de Yersinia pestis. L'invention concerne également des compositions renfermant de la flagelline comme adjuvant et un antigène de Yersinia pestis. L'invention concerne, en outre, des procédés de préparation de protéine hybride comprenant de la flagelline comme adjuvant et un antigène de Yersinia pestis. L'invention concerne enfin des formulations pharmaceutiques et des procédés permettant d'induire une réponse immune contre Yersinia pestis.

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