Treatment to reduce edema for brain and musculature injuries

A - Human Necessities – 61 – K

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A61K 38/35 (2006.01) A01N 1/02 (2006.01) A61K 38/22 (2006.01)

Patent

CA 2064039

Administration of a Corticotropin-Releasing Factor (or a salt or analog thereof) decreases the leakage of blood components into brain tissue produced by various adverse medical condition and reduces bleeding when muscle tissues are cut and handled, such as in plastic and reconstructive surgery. A method of treating a patient for injury to or disease of the brain, central nervous system, or musculature in which edema is a factor comprises administering to the patient a Corticotropin-Releasing Factor (or a salt or analog) in an amount effective to decrease vascular permeability in the injured or diseased brain, nervous system tissue or musculature, and thereby to reduce edema. Administration in accordance with the method can be about two hours before surgery, or can be up to three days after injury.

L'administration d'un facteur (d'un sel ou d'un analogue de celui-ci) de libération de corticotropine diminue la fuite de composants du sang dans les tissus cérébraux, résultant de divers états médicaux défavorables, et réduit le saignement lorsque l'on coupe et lorsque l'on manipule des tissus musculaires par exemple en chirurgie plastique et réparatrice. Un procédé de traitement des lésions ou de maladies du cerveau, du système nerveux central, ou de la musculature d'un patient, dans lesquelles l'oedème constitue un facteur, consiste à administrer au patient un facteur (un sel ou un analogue) de libération de corticotropine en une quantité efficace pour réduire la perméabilité vasculaire dans le cerveau lésé ou malade, les tissus ou la musculature du système nerveux, et ainsi à réduire l'oedème. L'administration selon le procédé peut avoir lieu environ deux heures avant la chirurgie, et jusqu'à trois jours après les lésions.

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