Heterocycle substituted amide and sulfur amide derivatives...

Details Heterocycle substituted amide and sulfur amide derivatives... Heterocycle substituted amide and sulfur amide derivatives...

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2627423

The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. Compounds of the present invention are useful for treating or preventing neurodegenerative diseases, schizophrenia and stroke among other diseases.

L'invention concerne des composés de formule (I): ou un sel, un stéréoisomère ou un tautomère de ceux-ci acceptable sur le plan pharmaceutique. Les composés de l'invention sont des inhibiteurs d'histone désacétylase (HDAC) et sont utiles dans le traitement de maladies à prolifération cellulaire, telles que que le cancer. Ces composés sont également utiles dans le traitement ou la prévention de maladies neurodégénératives, telles que, entre autres, la schizophrénie et l'accident vasculaire cérébral.

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